Model for transition from waves to synchrony in the olfactory lobe of Limax

Bard Ermentrout, Jing W. Wang, Jorge Flores, Alan Gelperin

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.

Original languageEnglish (US)
Pages (from-to)365-383
Number of pages19
JournalJournal of Computational Neuroscience
Volume17
Issue number3
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Keywords

  • Gap junctions
  • Limax
  • Nitric oxide
  • Olfaction
  • Oscillations
  • Waves

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