Model for transition from waves to synchrony in the olfactory lobe of Limax

Bard Ermentrout; Jing W. Wang; Jorge Flores; Alan Gelperin

doi:10.1023/B:JCNS.0000044877.21949.44

Model for transition from waves to synchrony in the olfactory lobe of Limax

Bard Ermentrout, Jing W. Wang, Jorge Flores, Alan Gelperin

Princeton Neuroscience Institute

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.

Original language	English (US)
Pages (from-to)	365-383
Number of pages	19
Journal	Journal of Computational Neuroscience
Volume	17
Issue number	3
DOIs	https://doi.org/10.1023/B:JCNS.0000044877.21949.44
State	Published - 2004

All Science Journal Classification (ASJC) codes

Sensory Systems
Cognitive Neuroscience
Cellular and Molecular Neuroscience

Keywords

Gap junctions
Limax
Nitric oxide
Olfaction
Oscillations
Waves

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10.1023/B:JCNS.0000044877.21949.44

Cite this

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title = "Model for transition from waves to synchrony in the olfactory lobe of Limax",

abstract = "A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.",

keywords = "Gap junctions, Limax, Nitric oxide, Olfaction, Oscillations, Waves",

author = "Bard Ermentrout and Wang, {Jing W.} and Jorge Flores and Alan Gelperin",

note = "Funding Information: Alan Gelperin was supported by NIH MH56090 and GBE was supported by NSF DMS 0209942.",

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T1 - Model for transition from waves to synchrony in the olfactory lobe of Limax

AU - Ermentrout, Bard

AU - Wang, Jing W.

AU - Flores, Jorge

AU - Gelperin, Alan

N1 - Funding Information: Alan Gelperin was supported by NIH MH56090 and GBE was supported by NSF DMS 0209942.

PY - 2004

Y1 - 2004

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AB - A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.

KW - Gap junctions

KW - Limax

KW - Nitric oxide

KW - Olfaction

KW - Oscillations

KW - Waves

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Model for transition from waves to synchrony in the olfactory lobe of Limax

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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