Mitosis-associated repression in development

Emilia Esposito, Bomyi Lim, Ghita Guessous, Hanieh Falahati, Michael Levine

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Transcriptional repression is a pervasive feature of animal development. Here, we employ live-imaging methods to visualize the Snail repressor, which establishes the boundary between the presumptive mesoderm and neurogenic ectoderm of early Drosophila embryos. Snail target enhancers were attached to an MS2 reporter gene, permitting detection of nascent transcripts in living embryos. The transgenes exhibit initially broad patterns of transcription but are refined by repression in the mesoderm following mitosis. These observations reveal a correlation between mitotic silencing and Snail repression. We propose that mitosis and other inherent discontinuities in transcription boost the activities of sequence-specific repressors, such as Snail.

Original languageEnglish (US)
Pages (from-to)1503-1508
Number of pages6
JournalGenes and Development
Issue number13
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


  • Drosophila embryo
  • Live imaging
  • Mitosis
  • Repression
  • Transcription


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