MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Yujie Deng, Zhenxia Huang, Yanjun Xu, Juan Jin, Wei Zhuo, Cheng Zhang, Xuting Zhang, Minhong Shen, Xiaoyi Yan, Liangjing Wang, Xiaojia Wang, Yibin Kang, Jianmin Si, Tianhua Zhou

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalCancer Letters
Volume342
Issue number1
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Gastric cancer
  • MiR-215
  • Proliferation
  • Retinoblastoma

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