MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Yujie Deng; Zhenxia Huang; Yanjun Xu; Juan Jin; Wei Zhuo; Cheng Zhang; Xuting Zhang; Minhong Shen; Xiaoyi Yan; Liangjing Wang; Xiaojia Wang; Yibin Kang; Jianmin Si; Tianhua Zhou

doi:10.1016/j.canlet.2013.08.033

MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Yujie Deng, Zhenxia Huang, Yanjun Xu, Juan Jin, Wei Zhuo, Cheng Zhang, Xuting Zhang, Minhong Shen, Xiaoyi Yan, Liangjing Wang, Xiaojia Wang, Yibin Kang, Jianmin Si, Tianhua Zhou

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

Original language	English (US)
Pages (from-to)	27-35
Number of pages	9
Journal	Cancer Letters
Volume	342
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.08.033
State	Published - Jan 1 2014

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

Gastric cancer
MiR-215
Proliferation
Retinoblastoma

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10.1016/j.canlet.2013.08.033

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title = "MiR-215 modulates gastric cancer cell proliferation by targeting RB1",

abstract = "Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.",

keywords = "Gastric cancer, MiR-215, Proliferation, Retinoblastoma",

author = "Yujie Deng and Zhenxia Huang and Yanjun Xu and Juan Jin and Wei Zhuo and Cheng Zhang and Xuting Zhang and Minhong Shen and Xiaoyi Yan and Liangjing Wang and Xiaojia Wang and Yibin Kang and Jianmin Si and Tianhua Zhou",

note = "Funding Information: We thank Can Chen and Wei Zhang for technical support. This work was supported by Natural Scientific Foundation of China (31071221, 31190063, 31125017 and 31100975), Ministry of Science and Technology of China (2013CB945603, 2012CB945004 and 2011CBA01001), Ministry of Education of China (20110101110103), Natural Scientific Foundation of Zhejiang Province, China (LQ13H160013, Z2100247 and Y2100106), the 111 Project (B13026), Department of Science and Technology of Zhejiang Province (2009C03012-3 and 2009F80005) and Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents. ",

year = "2014",

month = jan,

day = "1",

doi = "10.1016/j.canlet.2013.08.033",

language = "English (US)",

volume = "342",

pages = "27--35",

journal = "Cancer Letters",

issn = "0304-3835",

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T1 - MiR-215 modulates gastric cancer cell proliferation by targeting RB1

AU - Deng, Yujie

AU - Huang, Zhenxia

AU - Xu, Yanjun

AU - Jin, Juan

AU - Zhuo, Wei

AU - Zhang, Cheng

AU - Zhang, Xuting

AU - Shen, Minhong

AU - Yan, Xiaoyi

AU - Wang, Liangjing

AU - Wang, Xiaojia

AU - Kang, Yibin

AU - Si, Jianmin

AU - Zhou, Tianhua

N1 - Funding Information: We thank Can Chen and Wei Zhang for technical support. This work was supported by Natural Scientific Foundation of China (31071221, 31190063, 31125017 and 31100975), Ministry of Science and Technology of China (2013CB945603, 2012CB945004 and 2011CBA01001), Ministry of Education of China (20110101110103), Natural Scientific Foundation of Zhejiang Province, China (LQ13H160013, Z2100247 and Y2100106), the 111 Project (B13026), Department of Science and Technology of Zhejiang Province (2009C03012-3 and 2009F80005) and Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

AB - Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

KW - Gastric cancer

KW - MiR-215

KW - Proliferation

KW - Retinoblastoma

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MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Abstract

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