TY - GEN
T1 - Minimal reaction network for bistability in the MAPK signalling cascade
AU - Hadač, O.
AU - Schreiber, I.
AU - Přibyl, M.
AU - Shvartsman, S. Y.
PY - 2012
Y1 - 2012
N2 - Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. The MAPK cascade is one of the most studied signalling biochemical pathways. This biochemical network involves many proteins, including MAPKs, which communicate by adding phosphate groups to a neighbouring protein, which in turn acts as an "on" or "off" switch. The cascade is well conserved and always consists of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. The work examined the MAPK cascade described by the Ferrell-Huang model. We used methods of the stoichiometric networks analysis and nonlinear dynamics to reduce the network and obtain minimal reaction network for bistability in the MAPK signalling cascade. Finally, we studied properties of the core model for bistability.
AB - Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. The MAPK cascade is one of the most studied signalling biochemical pathways. This biochemical network involves many proteins, including MAPKs, which communicate by adding phosphate groups to a neighbouring protein, which in turn acts as an "on" or "off" switch. The cascade is well conserved and always consists of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. The work examined the MAPK cascade described by the Ferrell-Huang model. We used methods of the stoichiometric networks analysis and nonlinear dynamics to reduce the network and obtain minimal reaction network for bistability in the MAPK signalling cascade. Finally, we studied properties of the core model for bistability.
KW - Bistability
KW - MAPK cascade
KW - Stoichiometric network analysis
UR - http://www.scopus.com/inward/record.url?scp=84871780414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871780414&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84871780414
SN - 9780816910731
T3 - AIChE Annual Meeting, Conference Proceedings
BT - AIChE 2012 - 2012 AIChE Annual Meeting, Conference Proceedings
T2 - 2012 AIChE Annual Meeting, AIChE 2012
Y2 - 28 October 2012 through 2 November 2012
ER -