Minimal reaction network for bistability in the MAPK signalling cascade

O. Hadač, I. Schreiber, M. Přibyl, S. Y. Shvartsman

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. The MAPK cascade is one of the most studied signalling biochemical pathways. This biochemical network involves many proteins, including MAPKs, which communicate by adding phosphate groups to a neighbouring protein, which in turn acts as an "on" or "off" switch. The cascade is well conserved and always consists of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. The work examined the MAPK cascade described by the Ferrell-Huang model. We used methods of the stoichiometric networks analysis and nonlinear dynamics to reduce the network and obtain minimal reaction network for bistability in the MAPK signalling cascade. Finally, we studied properties of the core model for bistability.

Original languageEnglish (US)
Title of host publicationAIChE 2012 - 2012 AIChE Annual Meeting, Conference Proceedings
StatePublished - 2012
Event2012 AIChE Annual Meeting, AIChE 2012 - Pittsburgh, PA, United States
Duration: Oct 28 2012Nov 2 2012

Publication series

NameAIChE Annual Meeting, Conference Proceedings


Other2012 AIChE Annual Meeting, AIChE 2012
Country/TerritoryUnited States
CityPittsburgh, PA

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering
  • General Chemistry


  • Bistability
  • MAPK cascade
  • Stoichiometric network analysis


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