@article{c271059953da4caa800364f346bfeb1f,
title = "Midbrain raphe neurons: Spontaneous activity and response to light",
abstract = "A quantitative computer analysis was made of the spontaneous activity of 46 midbrain raphe units in the anesthetized rat. These units are characterized by a slow and rhythmic discharge rate which remains stable over time. Cells in the dorsal raphe, median raphe and brachium conjunctivum did not differ in this respect. A subpopulation of cells in the dorsal raphe exhibited regular, periodic oscillations in discharge rate. Response of raphe units to light flashes and light and dark conditions was also studied. Of 44 units tested, there was a tendency toward higher rates of discharge in the light. Effects of light flashes were examined in 34 units. Raphe cells were typically unresponsive to light flashes.",
keywords = "Anesthetized rats, Environmental lighting, ISI histogram, Raphe neurons, Spontaneous activity",
author = "Mosko, {Sarah S.} and Jacobs, {Barry L.}",
note = "Funding Information: Ceils of the dorsal and median raphe nuclei were studied in 56 male Sprague-Dawley rats (300-400 g) maintained on a 24-hr light-dark cycle (lights on at 2200 hours; off at 1000 hours). Rats were anesthetized with chloral hydrate (400 mg/kg i.p.). Tungsten microelectrodes (tip diameter 1-2 #M) with impedance ranging from 1.5-4.0 Mf~ were lowered into the region of the midbrain raphe. Raphe units were identified by their characteristically slow and rhythmic spike rate [4,5]. With the bite bar 5.0 mm above horizontal zero, cells of the dorsal raphe nucleus were typically encountered at A 0.5 -0.65, L 0.0 and H (-) 0.3 - (-) 1.5, while median raphe units were found at H (-) 1.8-(-) 3.0. In addition, ceils showing the same fh-'ing pattern as This investigation was supported by grants MH 24771 and MH 23433 from the National Institute of Mental Health, and the Spencer Foundation. We wish to thank Daniel Ruimy and Donna Kirk for their assistance in various phases of these studies.",
year = "1974",
month = oct,
doi = "10.1016/0031-9384(74)90292-3",
language = "English (US)",
volume = "13",
pages = "589--593",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "4",
}