Microinversions in mammalian evolution

M. J. Chaisson, B. J. Raphael, F. A. Pevzner

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as " certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phytogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.

Original languageEnglish (US)
Pages (from-to)19824-19829
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number52
StatePublished - Dec 26 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


  • Genome rearrangements
  • Phylogenetics


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