Microinjected clonidine inhibits noradrenergic neurons of the locus coeruleus in freely moving cats

Elizabeth D. Abercrombie, Barry L. Jacobs

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Microinjection of the α2-adrenoceptor agonist, clonidine (CLON; 1.0 μg 0.1 μl) effected a virtually complete suppression of the spontaneous activity of noradrenergic neurons of the locus coeruleus in freely moving cats. This effect lasted for approximately 90 min and was reversible by systemic administration of the α2-adrenoceptor antagonist, yohimbine. In contrast, CLON had no consistent effect on the activity of neighboring non-noradrenergic neurons. These results provide additional evidence for the direct inhibition of central noradrenergic neurons by CLON by demonstrating such effects independent of anesthesia or the behavioral effects of systemic drug administration. More generally, these findings demonstrate the usefulness of a technique in which small amounts of drug can be applied in small volumes to produce a neuropharmacologically specific effect upon locally recorded neurons in behaving animals.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalNeuroscience Letters
Volume76
Issue number2
DOIs
StatePublished - May 6 1987

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Cat
  • Clonidine
  • Locus coeruleus
  • Microinjection
  • Noradrenaline
  • Single unit activity

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