Microfluidic high gradient magnetic cell separation

David W. Inglis; Robert Riehn; James C. Sturm; Robert H. Austin

doi:10.1063/1.2165782

Microfluidic high gradient magnetic cell separation

David W. Inglis, Robert Riehn, James C. Sturm, Robert H. Austin

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

Original language	English (US)
Article number	08K101
Journal	Journal of Applied Physics
Volume	99
Issue number	8
DOIs	https://doi.org/10.1063/1.2165782
State	Published - 2006

All Science Journal Classification (ASJC) codes

General Physics and Astronomy

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10.1063/1.2165782

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title = "Microfluidic high gradient magnetic cell separation",

abstract = "Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.",

author = "Inglis, {David W.} and Robert Riehn and Sturm, {James C.} and Austin, {Robert H.}",

note = "Funding Information: This work was supported by grants from DARPA (MDA972-00-1-0031), NIH (HG01506), (E21F46G1), NSF Nanobiology Technology Center (BSCECS9876771), and the State of New Jersey (NJCST 99-100-082-2042-007).",

year = "2006",

doi = "10.1063/1.2165782",

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T1 - Microfluidic high gradient magnetic cell separation

AU - Inglis, David W.

AU - Riehn, Robert

AU - Sturm, James C.

AU - Austin, Robert H.

N1 - Funding Information: This work was supported by grants from DARPA (MDA972-00-1-0031), NIH (HG01506), (E21F46G1), NSF Nanobiology Technology Center (BSCECS9876771), and the State of New Jersey (NJCST 99-100-082-2042-007).

PY - 2006

Y1 - 2006

N2 - Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

AB - Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

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Microfluidic high gradient magnetic cell separation

Abstract

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