Microfluidic high gradient magnetic cell separation

David W. Inglis, Robert Riehn, James C. Sturm, Robert H. Austin

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

Original languageEnglish (US)
Article number08K101
JournalJournal of Applied Physics
Volume99
Issue number8
DOIs
StatePublished - May 25 2006

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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