Microfluidic flow focusing: Drop size and scaling in pressure versus flow-rate-driven pumping

Thomas Ward, Magalie Faivre, Manouk Abkarian, Howard A. Stone

Research output: Contribution to journalArticlepeer-review

245 Scopus citations

Abstract

We experimentally study the production of micrometer-sized droplets using microfluidic technology and a flow-focusing geometry. Two distinct methods of flow control are compared: (i) control of the flow rates of the two phases and (ii) control of the inlet pressures of the two phases. In each type of experiment, the drop size /, velocity U and production frequency f are measured and compared as either functions of the flow-rate ratio or the inlet pressure ratio. The minimum drop size in each experiment is on the order of the flow focusing contraction width a. The variation in drop size as the flow control parameters are varied is significantly different between the flow-rate and inlet pressure controlled experiments.

Original languageEnglish (US)
Pages (from-to)3716-3724
Number of pages9
JournalELECTROPHORESIS
Volume26
Issue number19
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Keywords

  • Flow focusing
  • Microfluidics
  • Multiphase flow

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