Microbial metabolite as icebreaker for immunotherapy

Yong Tang; Yibin Kang

doi:10.1016/j.cmet.2022.03.003

Microbial metabolite as icebreaker for immunotherapy

Yong Tang, Yibin Kang

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8⁺ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

Original language	English (US)
Pages (from-to)	506-507
Number of pages	2
Journal	Cell Metabolism
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2022.03.003
State	Published - Apr 5 2022

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

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10.1016/j.cmet.2022.03.003

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@article{9fe35d79dd8f433ba695315401a6d028,

title = "Microbial metabolite as icebreaker for immunotherapy",

abstract = "Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).",

author = "Yong Tang and Yibin Kang",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = apr,

day = "5",

doi = "10.1016/j.cmet.2022.03.003",

language = "English (US)",

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number = "4",

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T1 - Microbial metabolite as icebreaker for immunotherapy

AU - Tang, Yong

AU - Kang, Yibin

PY - 2022/4/5

Y1 - 2022/4/5

N2 - Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

AB - Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

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U2 - 10.1016/j.cmet.2022.03.003

DO - 10.1016/j.cmet.2022.03.003

M3 - Comment/debate

C2 - 35385701

AN - SCOPUS:85127294098

SN - 1550-4131

VL - 34

SP - 506

EP - 507

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Microbial metabolite as icebreaker for immunotherapy

Abstract

All Science Journal Classification (ASJC) codes

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