Abstract
Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.
Original language | English (US) |
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Pages (from-to) | 1678-1692 |
Number of pages | 15 |
Journal | Analytical and Bioanalytical Chemistry |
Volume | 378 |
Issue number | 7 |
DOIs | |
State | Published - Apr 2004 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry