Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Barry Scott; Emily A. Day; Katie L. O’Brien; John Scanlan; Grace Cromwell; Aine Ni Scannail; Marie E. McDonnell; David K. Finlay; Lydia Lynch

doi:10.1038/s42255-024-01018-7

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay, Lydia Lynch

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.

Original language	English (US)
Pages (from-to)	651-658
Number of pages	8
Journal	Nature Metabolism
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/s42255-024-01018-7
State	Published - Apr 2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Cell Biology

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10.1038/s42255-024-01018-7

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title = "Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans",

abstract = "Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.",

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AU - Scanlan, John

AU - Cromwell, Grace

AU - Scannail, Aine Ni

AU - McDonnell, Marie E.

AU - Finlay, David K.

AU - Lynch, Lydia

PY - 2024/4

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AB - Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.

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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Abstract

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