Metastatic niche functions and therapeutic opportunities

Toni Celià-Terrassa; Yibin Kang

doi:10.1038/s41556-018-0145-9

Metastatic niche functions and therapeutic opportunities

Toni Celià-Terrassa
, Yibin Kang

Research output: Contribution to journal › Review article › peer-review

156 Scopus citations

Abstract

Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.

Original language	English (US)
Pages (from-to)	868-877
Number of pages	10
Journal	Nature cell biology
Volume	20
Issue number	8
DOIs	https://doi.org/10.1038/s41556-018-0145-9
State	Published - Aug 1 2018

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/s41556-018-0145-9

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AB - Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.

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Metastatic niche functions and therapeutic opportunities

Abstract

All Science Journal Classification (ASJC) codes

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