Metastatic niche functions and therapeutic opportunities

Toni Celià-Terrassa, Yibin Kang

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.

Original languageEnglish (US)
Pages (from-to)868-877
Number of pages10
JournalNature cell biology
Volume20
Issue number8
DOIs
StatePublished - Aug 1 2018

All Science Journal Classification (ASJC) codes

  • Cell Biology

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