TY - JOUR
T1 - Metastatic niche functions and therapeutic opportunities
AU - Celià-Terrassa, Toni
AU - Kang, Yibin
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.
AB - Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.
UR - http://www.scopus.com/inward/record.url?scp=85051479517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051479517&partnerID=8YFLogxK
U2 - 10.1038/s41556-018-0145-9
DO - 10.1038/s41556-018-0145-9
M3 - Review article
C2 - 30050120
AN - SCOPUS:85051479517
SN - 1465-7392
VL - 20
SP - 868
EP - 877
JO - Nature cell biology
JF - Nature cell biology
IS - 8
ER -