Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Emily L. Que; Dylan W. Domaille; Christopher J. Chang

doi:10.1021/cr078203u

Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Emily L. Que, Dylan W. Domaille, Christopher J. Chang

Research output: Contribution to journal › Review article › peer-review

1964 Scopus citations

Abstract

An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.

Original language	English (US)
Pages (from-to)	1517-1549
Number of pages	33
Journal	Chemical Reviews
Volume	108
Issue number	5
DOIs	https://doi.org/10.1021/cr078203u
State	Published - May 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1021/cr078203u

Cite this

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title = "Metals in neurobiology: Probing their chemistry and biology with molecular imaging",

abstract = "An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.",

author = "Que, \{Emily L.\} and Domaille, \{Dylan W.\} and Chang, \{Christopher J.\}",

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AB - An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.

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Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Abstract

All Science Journal Classification (ASJC) codes

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