Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Emily L. Que; Dylan W. Domaille; Christopher J. Chang

doi:10.1021/cr078203u

Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Emily L. Que, Dylan W. Domaille, Christopher J. Chang

Research output: Contribution to journal › Review article › peer-review

1947 Scopus citations

Abstract

An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.

Original language	English (US)
Pages (from-to)	1517-1549
Number of pages	33
Journal	Chemical Reviews
Volume	108
Issue number	5
DOIs	https://doi.org/10.1021/cr078203u
State	Published - May 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry

Access to Document

10.1021/cr078203u

Cite this

@article{efcff508acca476a85f3a039974b0a03,

title = "Metals in neurobiology: Probing their chemistry and biology with molecular imaging",

abstract = "An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.",

author = "Que, \{Emily L.\} and Domaille, \{Dylan W.\} and Chang, \{Christopher J.\}",

year = "2008",

month = may,

doi = "10.1021/cr078203u",

language = "English (US)",

volume = "108",

pages = "1517--1549",

journal = "Chemical Reviews",

issn = "0009-2665",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Metals in neurobiology

T2 - Probing their chemistry and biology with molecular imaging

AU - Que, Emily L.

AU - Domaille, Dylan W.

AU - Chang, Christopher J.

PY - 2008/5

Y1 - 2008/5

N2 - An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.

AB - An overview on the transition metals in neurobiology which focuses on d-block metals zinc, iron, and copper to neurophysiology, aging, and neuropathology is presented. A review is also given on the progress in the development of molecular probes for visualizing zinc, iron, and copper ion pools. Small-molecule synthetic reagents that have been used or may be used to probe zinc, iron and copper in biological settings have also been discussed.

UR - http://www.scopus.com/inward/record.url?scp=44849102395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44849102395&partnerID=8YFLogxK

U2 - 10.1021/cr078203u

DO - 10.1021/cr078203u

M3 - Review article

C2 - 18426241

AN - SCOPUS:44849102395

SN - 0009-2665

VL - 108

SP - 1517

EP - 1549

JO - Chemical Reviews

JF - Chemical Reviews

IS - 5

ER -

Metals in neurobiology: Probing their chemistry and biology with molecular imaging

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this