Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis

Amy Y. Chan, Ian B. Perry, Noah B. Bissonnette, Benito F. Buksh, Grant A. Edwards, Lucas I. Frye, Olivia L. Garry, Marissa N. Lavagnino, Beryl X. Li, Yufan Liang, Edna Mao, Agustin Millet, James V. Oakley, Nicholas L. Reed, Holt A. Sakai, Ciaran P. Seath, David W.C. MacMillan

Research output: Contribution to journalReview articlepeer-review

679 Scopus citations


The merger of photoredox catalysis with transition metal catalysis, termed metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past decade. Metallaphotoredox catalysis has combined the unparalleled capacity of transition metal catalysis for bond formation with the broad utility of photoinduced electron- and energy-transfer processes. Photocatalytic substrate activation has allowed the engagement of simple starting materials in metal-mediated bond-forming processes. Moreover, electron or energy transfer directly with key organometallic intermediates has provided novel activation modes entirely complementary to traditional catalytic platforms. This Review details and contextualizes the advancements in molecule construction brought forth by metallaphotocatalysis.

Original languageEnglish (US)
Pages (from-to)1485-1542
Number of pages58
JournalChemical Reviews
Issue number2
StatePublished - Jan 26 2022

All Science Journal Classification (ASJC) codes

  • General Chemistry


Dive into the research topics of 'Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis'. Together they form a unique fingerprint.

Cite this