Metallaphotoredox Difluoromethylation of Aryl Bromides

Vlad Bacauanu, Sébastien Cardinal, Motoshi Yamauchi, Masaru Kondo, David F. Fernández, Richard Remy, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.

Original languageEnglish (US)
Pages (from-to)12543-12548
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number38
StatePublished - Sep 17 2018

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Catalysis


  • difluoromethylation
  • fluorine
  • heterocycles
  • nickel
  • photoredox catalysis


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