Merging photoredox and nickel catalysis: Decarboxylative cross-coupling of carboxylic acids with vinyl halides

Adam Noble, Stefan J. McCarver, David W.C. Macmillan

Research output: Contribution to journalArticlepeer-review

264 Scopus citations

Abstract

Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild, operationally simple reaction conditions.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number2
DOIs
StatePublished - Jan 21 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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