Mechanotransduction, metastasis and genomic instability

Allison K. Simi, Alexandra S. Piotrowski, Celeste M. Nelson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cells translate mechanical forces in the environment into biochemical signals in a process called mechanotransduction. In this way, mechanical forces direct cell behavior, including motility, proliferation, and differentiation, and become important in physiological processes such as development and wound healing. Abnormalities in mechanotransduction can lead to aberrant cell behavior and disease, including cancer. Changes in extracellular mechanical forces or defects in mechanosensors can result in misregulation of signaling pathways inside the cell, and ultimately lead to malignancy. Here, we discuss the ways in which physical attributes of the tumor microenvironment can promote metastasis and genomic instability, two hallmark features of cancer.

Original languageEnglish (US)
Pages (from-to)139-158
Number of pages20
JournalCancer Metastasis - Biology and Treatment
Volume20
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • EMT
  • Mechanical stress
  • Stiffness

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