TY - JOUR
T1 - Mechanotransduction, metastasis and genomic instability
AU - Simi, Allison K.
AU - Piotrowski, Alexandra S.
AU - Nelson, Celeste M.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Cells translate mechanical forces in the environment into biochemical signals in a process called mechanotransduction. In this way, mechanical forces direct cell behavior, including motility, proliferation, and differentiation, and become important in physiological processes such as development and wound healing. Abnormalities in mechanotransduction can lead to aberrant cell behavior and disease, including cancer. Changes in extracellular mechanical forces or defects in mechanosensors can result in misregulation of signaling pathways inside the cell, and ultimately lead to malignancy. Here, we discuss the ways in which physical attributes of the tumor microenvironment can promote metastasis and genomic instability, two hallmark features of cancer.
AB - Cells translate mechanical forces in the environment into biochemical signals in a process called mechanotransduction. In this way, mechanical forces direct cell behavior, including motility, proliferation, and differentiation, and become important in physiological processes such as development and wound healing. Abnormalities in mechanotransduction can lead to aberrant cell behavior and disease, including cancer. Changes in extracellular mechanical forces or defects in mechanosensors can result in misregulation of signaling pathways inside the cell, and ultimately lead to malignancy. Here, we discuss the ways in which physical attributes of the tumor microenvironment can promote metastasis and genomic instability, two hallmark features of cancer.
KW - EMT
KW - Mechanical stress
KW - Stiffness
UR - http://www.scopus.com/inward/record.url?scp=84916229974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916229974&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-12136-9_7
DO - 10.1007/978-3-319-12136-9_7
M3 - Article
AN - SCOPUS:84916229974
VL - 20
SP - 139
EP - 158
JO - Cancer Metastasis - Biology and Treatment
JF - Cancer Metastasis - Biology and Treatment
SN - 1568-2102
ER -