Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes

Keyphrases

• Tryptophan 100%
• Lysine 100%
• Mechanistic Investigation 100%
• Radical S-adenosylmethionine Enzymes 100%
• Link Formation 100%
• Cyclization 50%
• Nucleophilic Aromatic Substitution 50%
• Indole 50%
• Mechanistic Aspects 50%
• Post-translational Modification 50%
• Side Chain 50%
• Enzyme Active Site 50%
• Bond-forming 50%
• Electrophilic Addition 50%
• Ribosomally Synthesized 50%
• Carbon-carbon Bond 50%
• Reaction Cycle 50%
• Modified Peptide 50%
• StrB 50%
• Precursor Peptide 50%
• Mechanistic Proposals 50%
• Catalytic Base 50%
• Substitution Mechanism 50%

Biochemistry, Genetics and Molecular Biology

• Electrophilicity 66%
• Streptococcus 33%

Chemistry

• Electrophilic Aromatic Substitution 50%