Mechanisms underlying spindle assembly and robustness

Venecia A. Valdez, Lila Neahring, Sabine Petry, Sophie Dumont

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The microtubule-based spindle orchestrates chromosome segregation during cell division. Following more than a century of study, many components and pathways contributing to spindle assembly have been described, but how the spindle robustly assembles remains incompletely understood. This process involves the self-organization of a large number of molecular parts — up to hundreds of thousands in vertebrate cells — whose local interactions give rise to a cellular-scale structure with emergent architecture, mechanics and function. In this Review, we discuss key concepts in our understanding of spindle assembly, focusing on recent advances and the new approaches that enabled them. We describe the pathways that generate the microtubule framework of the spindle by driving microtubule nucleation in a spatially controlled fashion and present recent insights regarding the organization of individual microtubules into structural modules. Finally, we discuss the emergent properties of the spindle that enable robust chromosome segregation.

Original languageEnglish (US)
Pages (from-to)523-542
Number of pages20
JournalNature Reviews Molecular Cell Biology
Volume24
Issue number8
DOIs
StatePublished - Aug 2023

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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