Mechanisms of Selective Antitumor Action of Cold Atmospheric Plasma-Derived Reactive Oxygen and Nitrogen Species

Georg Bauer, David B. Graves

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Transformed cells are subject to elimination through intercellular reactive oxygen/nitrogen species (RONS)-dependent apoptosis-inducing signaling. Tumor progression, therefore, requires expression of membrane-bound catalase. Recent research demonstrates that 1O2 can inactivate membrane-bound catalase, thus, inducing the generation of tumor cell-derived secondary 1O2 and RONS-dependent apoptosis selectively in tumor cells. Crucially, 1O2 signaling can result in self-perpetuating apoptotic signaling from cell-to-cell. It is known that CAP contains 1O2 and that certain CAP constituents can generate 1O2 in solution. The analysis of model experiments performed with defined RONS implies that CAP-derived 1O2 induces the mechanism through which CAP acts selectively against cancer cells in vitro and tumors in vivo. This hypothesis needs to be tested experimentally in order to establish its validity.

Original languageEnglish (US)
Pages (from-to)1157-1178
Number of pages22
JournalPlasma Processes and Polymers
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Polymers and Plastics

Keywords

  • catalase
  • cold atmospheric plasma
  • reactive oxygen/nitrogen species
  • singlet oxygen
  • tumor

Fingerprint

Dive into the research topics of 'Mechanisms of Selective Antitumor Action of Cold Atmospheric Plasma-Derived Reactive Oxygen and Nitrogen Species'. Together they form a unique fingerprint.

Cite this