Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs)

Li Cao, Truc Do, A. James Link

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.

Original languageEnglish (US)
JournalJournal of Industrial Microbiology and Biotechnology
Volume48
Issue number3-4
DOIs
StatePublished - Jun 4 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Keywords

  • Mechanism of action
  • Natural products
  • RiPPs

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