Mechanisms of action of LSD

B. L. Jacobs, M. E. Trulson

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


In this paper we have tried to explain the behavioral effects of LSD in terms of changes in the activity of single brain cells. As with any complex behavioral process and any centrally acting drug, a complete explanation will, of necessity, involve a good deal more then the activity of one set of neurons. There are also many unanswered questions about the actions of LSD, such as the precise mechanism underlying tolerance. An important sign of health and vitality in any scientific field is the ability to undergo change and revision. Neuroscience is at present one of the more vigorous fields of scientific investigation, and we therefore have no doubt that the story we have told will undergo significant modification and extension.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalAmerican Scientist
Issue number4
StatePublished - Dec 1 1979

All Science Journal Classification (ASJC) codes

  • General

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