Mechanism of macromolecular structure evolution in self-assembled lipid nanoparticles for siRNA delivery

Chemical Compounds

• Macromolecular Structure 96%
• Silencing RNA 96%
• Lipid 51%
• Nanoparticle 37%
• Structure-Activity Relationship 8%
• Small Interfering RNA 6%
• Disordered Structure 5%
• Excipient 5%
• Small Angle X-Ray Scattering 4%
• Encapsulation 4%
• Cubic Space Group 3%
• Hexagonal Space Group 3%
• Annealing 3%
• Dose 3%
• Pharmacokinetics 3%
• Buffer Solution 3%
• Ion 1%

Physics & Astronomy

• lipids 73%
• delivery 71%
• nanoparticles 50%
• self assembly 19%
• payloads 5%
• assembly 3%
• buffers 3%
• platforms 3%
• routes 3%
• preparation 3%
• dosage 3%
• optimization 3%
• products 2%
• annealing 2%
• kinetics 2%
• scattering 2%
• ions 2%
• x rays 2%

Engineering & Materials Science

• Lipids 100%
• Nanoparticles 73%
• Self assembly 24%
• X ray scattering 7%
• RNA 5%
• Kinetic parameters 5%
• Encapsulation 5%
• Annealing 4%
• Ions 4%