Mechanics of tissue morphogenesis

Michael J. Siedlik, Celeste M. Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


How are we made? How does the apparently (and perhaps, deceptively) simple fertilized egg transform from a sphere to the complex geometry of a mature organism? These questions, in one form or another, have fascinated scientists and laypeople for thousands of years. Some of the earliest ideas were that organisms develop from miniature versions of their adult selves, often referred to as homunculi or animalcules, hiding within the heads of sperm. This concept, of preformationism, was largely abandoned in the nineteenth century when the cell theory of life became the predominant viewpoint: all living things are made of cells and so development requires that the single fertilized egg divide successively to give rise to the differentiated cell types of the mature organism.

Original languageEnglish (US)
Title of host publicationCell and Matrix Mechanics
PublisherCRC Press
Number of pages24
ISBN (Electronic)9781466553828
ISBN (Print)9781466553811
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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