Mechanics of Development

Katharine Goodwin, Celeste M. Nelson

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Mechanical forces are integral to development—from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field.

Original languageEnglish (US)
Pages (from-to)240-250
Number of pages11
JournalDevelopmental cell
Volume56
Issue number2
DOIs
StatePublished - Jan 25 2021

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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