Mechanical Control of Cell Differentiation: Insights from the Early Embryo

Research output: Contribution to journalReview articlepeer-review

Abstract

Differentiation is the process by which a cell activates the expression of tissue-specific genes, downregulates the expression of potency markers, and acquires the phenotypic characteristics of its mature fate. The signals that regulate differentiation include biochemical and mechanical factors within the surrounding microenvironment. We describe recent breakthroughs in our understanding of the mechanical control mechanisms that regulate differentiation, with a specific emphasis on the differentiation events that build the early mouse embryo. Engineering approaches that reproducibly mimic the mechanical regulation of differentiation will permit new insights into early development and applications in regenerative medicine.

Original languageEnglish (US)
Pages (from-to)307-322
Number of pages16
JournalAnnual Review of Biomedical Engineering
Volume24
DOIs
StatePublished - 2022

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

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