TY - JOUR
T1 - Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster
AU - Overman, Katherine E.
AU - Choi, Daniel M.
AU - Leung, Kawai
AU - Shaevitz, Joshua W.
AU - Berman, Gordon J.
N1 - Funding Information:
K.E.O., and K.L., and G.J.B. were supported by NIMH (R01 MH115831-01), the Human Frontier Science Program (RGY0076/ 2018), and a Cottrell Scholar Award, a program of the Research Corporation for Science Advancement (25999). K.E.O. was supported by the NSF Physics of Living Systems Student Research Network (PHY-1806833). Experimental work and J.W.S and D.M.C. were supported by NIH R01 GM098090 and in part by the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2022 Overman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/2
Y1 - 2022/2
N2 - Aging affects almost all aspects of an organism—its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal’s behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly’s overall energy budget, suggesting potential connections between metabolism, aging, and behavior.
AB - Aging affects almost all aspects of an organism—its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal’s behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly’s overall energy budget, suggesting potential connections between metabolism, aging, and behavior.
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U2 - 10.1371/journal.pcbi.1009867
DO - 10.1371/journal.pcbi.1009867
M3 - Article
C2 - 35202388
AN - SCOPUS:85126072404
SN - 1553-734X
VL - 18
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 2
M1 - e1009867
ER -