TY - JOUR
T1 - Measuring and modeling whole-brain neural dynamics in Caenorhabditis elegans
AU - Randi, Francesco
AU - Leifer, Andrew M.
N1 - Funding Information:
We thank Matthew Creamer for the critical reading of the manuscript. This work was supported by National Institute of Neurological Disorders and Stroke of the National Institutes of Health under New Innovator Award number DP2NS116768 to AML and by the Simons Foundation through award SCGB 543003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. FR was supported by the Swartz Foundation .
Publisher Copyright:
© 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - The compact nervous system of the nematode Caenorhabditis elegans makes it a powerful playground to study how neural dynamics constrained by neuroanatomy generate neural function and behavior. The ability to record neural activity from the whole brain simultaneously in this worm has opened several research avenues and is providing insights into brain-wide neural coding of locomotion, sleep, and other behaviors. We review these findings and the development of new methods, including new microscopes, new genetic tools, and new modeling approaches. We conclude with a discussion of the role of theory in interpreting or driving new experiments in C. elegans and potential paths forward.
AB - The compact nervous system of the nematode Caenorhabditis elegans makes it a powerful playground to study how neural dynamics constrained by neuroanatomy generate neural function and behavior. The ability to record neural activity from the whole brain simultaneously in this worm has opened several research avenues and is providing insights into brain-wide neural coding of locomotion, sleep, and other behaviors. We review these findings and the development of new methods, including new microscopes, new genetic tools, and new modeling approaches. We conclude with a discussion of the role of theory in interpreting or driving new experiments in C. elegans and potential paths forward.
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U2 - 10.1016/j.conb.2020.11.001
DO - 10.1016/j.conb.2020.11.001
M3 - Review article
C2 - 33279794
AN - SCOPUS:85097131561
SN - 0959-4388
VL - 65
SP - 167
EP - 175
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -