Mathematics for cryo-electron microscopy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”. This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.

Original languageEnglish (US)
Title of host publicationInvited Lectures
EditorsBoyan Sirakov, Paulo Ney de Souza, Marcelo Viana
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages4013-4032
Number of pages20
ISBN (Electronic)9789813272934
StatePublished - Jan 1 2018
Event2018 International Congress of Mathematicians, ICM 2018 - Rio de Janeiro, Brazil
Duration: Aug 1 2018Aug 9 2018

Publication series

NameProceedings of the International Congress of Mathematicians, ICM 2018
Volume4

Conference

Conference2018 International Congress of Mathematicians, ICM 2018
CountryBrazil
CityRio de Janeiro
Period8/1/188/9/18

All Science Journal Classification (ASJC) codes

  • Mathematics(all)

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  • Cite this

    Singer, A. (2018). Mathematics for cryo-electron microscopy. In B. Sirakov, P. N. de Souza, & M. Viana (Eds.), Invited Lectures (pp. 4013-4032). (Proceedings of the International Congress of Mathematicians, ICM 2018; Vol. 4). World Scientific Publishing Co. Pte Ltd.