TY - GEN
T1 - Mathematics for cryo-electron microscopy
AU - Singer, Amit
N1 - Funding Information:
Partially supported by Award Number R01GM090200 from the NIGMS, FA9550-17-1-0291 from AFOSR, Simons Foundation Math+X Investigator Award, and the Moore Foundation Data-Driven Discovery Investigator Award. MSC2010: primary 92C55; secondary 68U10, 44A12, 62H12, 33C55, 90C22.
Funding Information:
Partially supported by Award Number R01GM090200 from the NIGMS, FA9550-17-1-0291 from AFOSR, Simons Foundation Math+X Investigator Award, and the Moore Foundation Data-Driven Discovery Investigator Award.
Publisher Copyright:
© ICM 2018.All rights reserved.
PY - 2018
Y1 - 2018
N2 - Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”. This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.
AB - Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”. This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.
UR - http://www.scopus.com/inward/record.url?scp=85086411913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086411913&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85086411913
T3 - Proceedings of the International Congress of Mathematicians, ICM 2018
SP - 4013
EP - 4032
BT - Invited Lectures
A2 - Sirakov, Boyan
A2 - de Souza, Paulo Ney
A2 - Viana, Marcelo
PB - World Scientific Publishing Co. Pte Ltd
T2 - 2018 International Congress of Mathematicians, ICM 2018
Y2 - 1 August 2018 through 9 August 2018
ER -