Mathematical models of morphogen gradients and their effects on gene expression

Stanislav Y. Shvartsman; Ruth E. Baker

doi:10.1002/wdev.55

Mathematical models of morphogen gradients and their effects on gene expression

Stanislav Y. Shvartsman, Ruth E. Baker

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

An introduction to mathematical models of pattern formation by morphogen gradients is presented, using the early embryo of the fruit fly Drosophila as the main experimental example. Analysis of morphogen gradient formation is based on the source-diffusion-degradation models and a formalism of local accumulation times. Transcriptional control by morphogens is discussed within the framework of thermodynamic site occupancy models of gene regulatory regions.

Original language	English (US)
Pages (from-to)	715-730
Number of pages	16
Journal	Wiley Interdisciplinary Reviews: Developmental Biology
Volume	1
Issue number	5
DOIs	https://doi.org/10.1002/wdev.55
State	Published - 2012

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology
Developmental Biology

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10.1002/wdev.55

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abstract = "An introduction to mathematical models of pattern formation by morphogen gradients is presented, using the early embryo of the fruit fly Drosophila as the main experimental example. Analysis of morphogen gradient formation is based on the source-diffusion-degradation models and a formalism of local accumulation times. Transcriptional control by morphogens is discussed within the framework of thermodynamic site occupancy models of gene regulatory regions.",

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Mathematical models of morphogen gradients and their effects on gene expression

Abstract

All Science Journal Classification (ASJC) codes

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