@article{368a7c2a25dc42de9870e66d3ee7baa8,
title = "Materials aspects in micro- and nanofluidic systems applied to biology",
abstract = "One of the key problems in microfabrication and especially nanofabrication applied to biology is materials selection. Proper materials must have mechanical stability and the ability to hermetically bond to other surfaces, yet not bind biological molecules. They must also be wettable by water and have good optical properties. In this article, we review some of the attempts to find materials for micro- and nanofluidic systems in biological applications that satisfy these rather conflicting constraints. We discuss the materials properties that make poly(dimethylsiloxane) or non-elastomeric materials more or less suitable for particular applications in biology. We also explore the effects and the importance of surface treatments for integrating biological objects into microfabricated and nanofabricated fluidic devices.",
keywords = "Biological, Fluidics, Nanoscale, Surface chemistry",
author = "Olgica Bakajin and Eric Fountain and Keith Morton and Chou, {Stephen Y.} and Sturm, {James C.} and Austin, {Robert H.}",
note = "Funding Information: The work of O. Bakajin was performed under the auspices of the U.S. Department of Energy by the University of California{\textquoteright}s Lawrence Livermore National Laboratory under contract W-7405-Eng-48 and partially supported by funding from the Human Frontiers Science Program and the Center for Biophotonics, an NSF Science and Technology Center, managed by the University of California, Davis, under cooperative agreement PHY 0120999. The work at Princeton University was supported by grants from DARPA (MDA972-00-1-0031), NIH (HG01506), the NSF Nanobiology Technology Center (BSCECS9876771, the State of New Jersey (NJCST 99-100-082-2042-007) and U.S. Genomics. It was also performed in part at the Cornell NanoScale Science and Technology Facility (CNF), which is supported by the National Science Foundation under grant ECS-9731293, its users, Cornell University and Industrial Affiliates. We thank Abraham Stroock for many useful suggestions to the text.",
year = "2006",
month = feb,
doi = "10.1557/mrs2006.24",
language = "English (US)",
volume = "31",
pages = "108--113",
journal = "MRS Bulletin",
issn = "0883-7694",
publisher = "Materials Research Society",
number = "2",
}