Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons

Derya Sargin, Revathy U. Chottekalapanda, Kristina E. Perit, Victoria Yao, Duong Chu, Daniel W. Sparks, Salina Kalik, Saige K. Power, Olga G. Troyanskaya, Eric F. Schmidt, Paul Greengard, Evelyn K. Lambe

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In mood disorders, psychomotor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and cognitive symptoms. Corticostriatal neurons in motor and somatosensory cortex are implicated in these symptoms, yet mechanisms of their vulnerability are unknown. Here, we demonstrate that S100a10 corticostriatal neurons exhibit distinct serotonin responses and have increased excitability, compared with S100a10-negative neurons. We reveal that prolonged social isolation disrupts the specific serotonin response which gets restored by chronic antidepressant treatment. We identify cell-type-specific transcriptional signatures in S100a10 neurons that contribute to serotonin responses and strongly associate with psychomotor and somatosensory function. Our studies provide a strong framework to understand the pathogenesis and create new avenues for the treatment of mood disorders.

Original languageEnglish (US)
Pages (from-to)1112-1129
Number of pages18
JournalMolecular Psychiatry
Volume25
Issue number5
DOIs
StatePublished - May 1 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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