@article{28ef1ee832244a4db62582611c009acd,
title = "Mapping Sub-Second Structure in Mouse Behavior",
abstract = "Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that 3D mouse pose dynamics are structured at the sub-second timescale. Computational modeling of these fast dynamics effectively describes mouse behavior as a series of reused and stereotyped modules with defined transition probabilities. We demonstrate this combined 3D imaging and machine learning method can be used to unmask potential strategies employed by the brain to adapt to the environment, to capture both predicted and previously hidden phenotypes caused by genetic or neural manipulations, and to systematically expose the global structure of behavior within an experiment. This work reveals that mouse body language is built from identifiable components and is organized in a predictable fashion; deciphering this language establishes an objective framework for characterizing the influence of environmental cues, genes and neural activity on behavior.",
author = "Wiltschko, {Alexander B.} and Johnson, {Matthew J.} and Giuliano Iurilli and Peterson, {Ralph E.} and Katon, {Jesse M.} and Pashkovski, {Stan L.} and Abraira, {Victoria E.} and Adams, {Ryan P.} and Datta, {Sandeep Robert}",
note = "Funding Information: We thank Michael Greenberg, Vanessa Ruta, David Ginty, Jesse Gray, Mike Springer, Aravi Samuel, Chris Harvey, Bernardo Sabatini, Rachel Wilson, Andreas Schaefer, and members of the Datta Lab for helpful comments on the manuscript; Joseph Bell for useful conversations; and Alexandra Nowlan and Christine Ashton for laboratory assistance. We thank David Roberson and Clifford Woolf for assistance with behavioral experiments and Ofer Mazor and Pavel Gorelik from the Research Instrumentation Core Facility for engineering support. We thank Sigrid Knemeyer for illustration assistance. Core facility support is provided by NIH grant P30 HD18655. A.B.W. is supported by an NSF Graduate Research Fellowship and is a Stuart H.Q. & Victoria Quan Fellow. G.I. is supported by the Human Frontiers Science Program. M.J.J. is supported by a fellowship from the Harvard/MIT Joint Grants program. S.L.P. is supported by an NSF Graduate Research Fellowship and is a Stuart H.Q. & Victoria Quan Fellow. R.P.A. is supported by NSF IIS-1421780. S.R.D. is supported by fellowships from the Burroughs Wellcome Fund, Searle Scholars Program, the Vallee Foundation, the McKnight Foundation, and the Khodadad Program; by the Fidelity Biosciences Research Initiative; by grants DP2OD007109 and RO11DC011558 from the NIH; and by the SFARI program and the Global Brain Initiative from the Simons Foundation. Code is available upon request ( datta.hms.harvard.edu/research.html ). Funding Information: We thank Michael Greenberg, Vanessa Ruta, David Ginty, Jesse Gray, Mike Springer, Aravi Samuel, Chris Harvey, Bernardo Sabatini, Rachel Wilson, Andreas Schaefer, and members of the Datta Lab for helpful comments on the manuscript; Joseph Bell for useful conversations; and Alexandra Nowlan and Christine Ashton for laboratory assistance. We thank David Roberson and Clifford Woolf for assistance with behavioral experiments and Ofer Mazor and Pavel Gorelik from the Research Instrumentation Core Facility for engineering support. We thank Sigrid Knemeyer for illustration assistance. Core facility support is provided by NIH grant P30 HD18655. A.B.W. is supported by an NSF Graduate Research Fellowship and is a Stuart H.Q. & Victoria Quan Fellow. G.I. is supported by the Human Frontiers Science Program. M.J.J. is supported by a fellowship from the Harvard/MIT Joint Grants program. S.L.P. is supported by an NSF Graduate Research Fellowship and is a Stuart H.Q. & Victoria Quan Fellow. R.P.A. is supported by NSF IIS-1421780. S.R.D. is supported by fellowships from the Burroughs Wellcome Fund, Searle Scholars Program, the Vallee Foundation, the McKnight Foundation, and the Khodadad Program; by the Fidelity Biosciences Research Initiative; by grants DP2OD007109 and RO11DC011558 from the NIH; and by the SFARI program and the Global Brain Initiative from the Simons Foundation. Code is available upon request (datta.hms.harvard.edu/research.html). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
doi = "10.1016/j.neuron.2015.11.031",
language = "English (US)",
volume = "88",
pages = "1121--1135",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}