Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

Michael A. Skinnider, Mopelola O. Akinlaja, Leonard J. Foster

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.

Original languageEnglish (US)
Article number8365
JournalNature communications
Volume14
Issue number1
DOIs
StatePublished - Dec 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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