TY - JOUR
T1 - Manipulating proteins with chemistry
T2 - A cross-section of chemical biology
AU - Hahn, Michael E.
AU - Muir, Tom W.
N1 - Funding Information:
Work in the authors' laboratory is supported by NIH grants (GM55843, EB001991) and The Rockefeller University. M.E.H. is supported by a NIH Medical Scientist Training grant (GM07739).
PY - 2005/1
Y1 - 2005/1
N2 - Chemistry-driven strategies for modifying, controlling and monitoring protein function in vitro and in vivo have attracted widespread interest among chemists in recent years. Several strategies have now emerged that complement standard genetics-based approaches, and they are being increasingly adopted by biologists to address issues in relevant contexts from cells to animals. With the development of these chemical biology tools, we might be approaching a time when detailed quantitative analysis of protein function, to a degree previously available only in reconstituted systems, is attainable in an in vivo setting.
AB - Chemistry-driven strategies for modifying, controlling and monitoring protein function in vitro and in vivo have attracted widespread interest among chemists in recent years. Several strategies have now emerged that complement standard genetics-based approaches, and they are being increasingly adopted by biologists to address issues in relevant contexts from cells to animals. With the development of these chemical biology tools, we might be approaching a time when detailed quantitative analysis of protein function, to a degree previously available only in reconstituted systems, is attainable in an in vivo setting.
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U2 - 10.1016/j.tibs.2004.10.010
DO - 10.1016/j.tibs.2004.10.010
M3 - Review article
C2 - 15653323
AN - SCOPUS:11844291287
SN - 0968-0004
VL - 30
SP - 26
EP - 34
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -