Manganese-catalyzed oxidative benzylic C-H fluorination by fluoride ions

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Abstract

An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30min) to allow adoption for the incorporation of 18F fluoride sources for PET imaging applications.

Original languageEnglish (US)
Pages (from-to)6024-6027
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number23
DOIs
StatePublished - Jun 3 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • C-H fluorination
  • manganese
  • porphyrins
  • positron emission tomography
  • synthetic methods

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