Manganese-catalyzed oxidative benzylic C-H fluorination by fluoride ions

Wei Liu; John Taylor Groves

doi:10.1002/anie.201301097

Manganese-catalyzed oxidative benzylic C-H fluorination by fluoride ions

Wei Liu, John Taylor Groves

Research output: Contribution to journal › Article › peer-review

220 Scopus citations

Abstract

An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30min) to allow adoption for the incorporation of ¹⁸F fluoride sources for PET imaging applications.

Original language	English (US)
Pages (from-to)	6024-6027
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	23
DOIs	https://doi.org/10.1002/anie.201301097
State	Published - Jun 3 2013

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

Keywords

C-H fluorination
manganese
porphyrins
positron emission tomography
synthetic methods

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10.1002/anie.201301097

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abstract = "An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30min) to allow adoption for the incorporation of 18F fluoride sources for PET imaging applications.",

keywords = "C-H fluorination, manganese, porphyrins, positron emission tomography, synthetic methods",

author = "Wei Liu and Groves, {John Taylor}",

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AU - Groves, John Taylor

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AB - An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30min) to allow adoption for the incorporation of 18F fluoride sources for PET imaging applications.

KW - C-H fluorination

KW - manganese

KW - porphyrins

KW - positron emission tomography

KW - synthetic methods

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ER -

Manganese-catalyzed oxidative benzylic C-H fluorination by fluoride ions

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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