Mammary tumors induced by human adenovirus type 9: A role for the viral early region 4 gene

Ronald Javier, Thomas Eugene Shenk

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Human adenovirus type 9 (Ad9) elicits exclusively estrogen-dependent mammary tumors when injected into female rats. Three different histological types of mammary tumor (benign fibroadenomas, phyllodes tumors, and malignant solid sarcomas) have been described in Ad9-infected animals, with benign fibroadenomas being seen most frequently. Interestingly, in contrast to other adenoviruses, in which oncogenic viral functions are entirely encoded within the E1 region, Ad9 requires an E4 region transforming protein (ORF1) for its unique mammary oncogenicity. Studies of Ad9-induced rat mammary tumors may lead to a detailed molecular understanding for the development of fibroadenoma, a common human breast tumor.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalBreast Cancer Research and Treatment
Volume39
Issue number1
DOIs
StatePublished - May 20 1996

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Ad9
  • Adenovirus
  • E4 region
  • Estrogen
  • Fibroadenoma
  • Mammary gland
  • ORF1
  • Phyllodes tumor

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