Males induce premature demise of the opposite sex by multifaceted strategies

Lauren N. Booth, Cheng Shi, Cindy Tantilert, Robin W. Yeo, Jason W. Miklas, Katja Hebestreit, Cecilia N. Hollenhorst, Travis J. Maures, Matthew T. Buckley, Coleen T. Murphy, Anne Brunet

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Interactions between the sexes negatively impact health in many species. In Caenorhabditis, males shorten the lifespan of the opposite sex—hermaphrodites or females. Here we use transcriptomic profiling and targeted screens to systematically uncover conserved genes involved in male-induced demise in C. elegans. Some genes (for example, delm-2, acbp-3), when knocked down, are specifically protective against male-induced demise. Others (for example, sri-40), when knocked down, extend lifespan with and without males, suggesting general mechanisms of protection. In contrast, many classical long-lived mutants are impacted more negatively than wild type by the presence of males, highlighting the importance of sexual environment for longevity. Interestingly, genes induced by males are triggered by specific male components (seminal fluid, sperm and pheromone), and manipulating these genes in combination in hermaphrodites induces stronger protection. One of these genes, the conserved ion channel delm-2, acts in the nervous system and intestine to regulate lipid metabolism. Our analysis reveals striking differences in longevity in single sex versus mixed sex environments and uncovers elaborate strategies elicited by sexual interactions that could extend to other species.

Original languageEnglish (US)
Pages (from-to)809-823
Number of pages15
JournalNature Aging
Volume2
Issue number9
DOIs
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology
  • Neuroscience (miscellaneous)

Fingerprint

Dive into the research topics of 'Males induce premature demise of the opposite sex by multifaceted strategies'. Together they form a unique fingerprint.

Cite this