Making bacteria behave: New agonists and antagonists of quorum sensing

Megan E. Pomianek, M. F. Semmelhack

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Small-molecule agonists and antagonists of bacterial quorum sensing can enhance our understanding of this form of cell-cell communication. A recent effort has discovered effective modulators of the autoinducer-1 circuit for bacterial quorum sensing by the synthesis and evaluation of a small library of aryl-substituted acyl-homoserine lactone analogues. This series highlights the sensitivity to structure of the contrasting responses of agonism and antagonism of the natural signal and identifies an analogue that provokes the same response as the natural signal but at 10-fold lower concentration, a "superagonist".

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalACS chemical biology
Issue number5
StatePublished - May 2007

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Biochemistry


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