Making a beta-barrel: Assembly of outer membrane proteins in Gram-negative bacteria

Nathan W. Rigel, Thomas J. Silhavy

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

The outer membrane (OM) of Gram-negative bacteria is an essential organelle that serves as a selective permeability barrier by keeping toxic compounds out of the cell while allowing vital nutrients in. How the OM and its constituent lipid and protein components are assembled remains an area of active research. In this review, we describe our current understanding of how outer membrane proteins (OMPs) are delivered to and then assembled in the OM of the model Gram-negative organism Escherichia coli.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalCurrent opinion in microbiology
Volume15
Issue number2
DOIs
StatePublished - Apr 2012

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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