Making a beta-barrel: Assembly of outer membrane proteins in Gram-negative bacteria

Nathan W. Rigel; Thomas J. Silhavy

doi:10.1016/j.mib.2011.12.007

Making a beta-barrel: Assembly of outer membrane proteins in Gram-negative bacteria

Nathan W. Rigel, Thomas J. Silhavy

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

The outer membrane (OM) of Gram-negative bacteria is an essential organelle that serves as a selective permeability barrier by keeping toxic compounds out of the cell while allowing vital nutrients in. How the OM and its constituent lipid and protein components are assembled remains an area of active research. In this review, we describe our current understanding of how outer membrane proteins (OMPs) are delivered to and then assembled in the OM of the model Gram-negative organism Escherichia coli.

Original language	English (US)
Pages (from-to)	189-193
Number of pages	5
Journal	Current opinion in microbiology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.mib.2011.12.007
State	Published - Apr 2012

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Microbiology

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10.1016/j.mib.2011.12.007

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abstract = "The outer membrane (OM) of Gram-negative bacteria is an essential organelle that serves as a selective permeability barrier by keeping toxic compounds out of the cell while allowing vital nutrients in. How the OM and its constituent lipid and protein components are assembled remains an area of active research. In this review, we describe our current understanding of how outer membrane proteins (OMPs) are delivered to and then assembled in the OM of the model Gram-negative organism Escherichia coli.",

author = "Rigel, {Nathan W.} and Silhavy, {Thomas J.}",

note = "Funding Information: This work was supported by NIH postdoctoral fellowship GM093768 (NWR) and National Institute of General Medical Sciences grant GM34821 (TJS). We thank Holly Cardoso, Penny Mahoney, and Dante Ricci for reading the manuscript. ",

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Making a beta-barrel: Assembly of outer membrane proteins in Gram-negative bacteria

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