LuxS quorum sensing: More than just a numbers game

Karina B. Xavier, Bonnie L. Bassler

Research output: Contribution to journalReview articlepeer-review

558 Scopus citations


Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extracellular signaling molecules called autoinducers. Quorum sensing allows populations of bacteria to collectively control gene expression, and thus synchronize group behavior. Processes controlled by quorum sensing are typically ones that are unproductive unless many bacteria act together. Most autoinducers enable intraspecies communication; however, a recently discovered autoinducer Al-2 has been proposed to serve as a 'universal signal' for interspecies communication. Studies suggest that Al-2 encodes information in addition to specifics about cell number.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalCurrent opinion in microbiology
Issue number2
StatePublished - Apr 2003

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Microbiology


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