Low-Dimensional Spatiotemporal Dynamics Underlie Cortex-wide Neural Activity

Camden J. MacDowell, Timothy J. Buschman

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Behaviors arise from the flow of neural activity through the brain. MacDowell and Buschman show cortex-wide neural activity, in mice, can be explained by a set of 14 motifs, each capturing a unique spatiotemporal pattern of neural activity. Motifs generalized across animals and behaviors, suggesting that they capture core patterns of cortical activity.

Original languageEnglish (US)
Pages (from-to)2665-2680.e8
JournalCurrent Biology
Issue number14
StatePublished - Jul 20 2020

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


  • calcium imaging
  • cognitive control
  • dimensionality of neural activity
  • mesoscale imaging
  • mouse
  • neural dynamics


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