Looping back to leap forward: Transcription enters a new era

Michael Levine, Claudia Cattoglio, Robert Tjian

Research output: Contribution to journalReview articlepeer-review

260 Scopus citations

Abstract

Comparative genome analyses reveal that organismal complexity scales not with gene number but with gene regulation. Recent efforts indicate that the human genome likely contains hundreds of thousands of enhancers, with a typical gene embedded in a milieu of tens of enhancers. Proliferation of cis-regulatory DNAs is accompanied by increased complexity and functional diversification of transcriptional machineries recognizing distal enhancers and core promoters and by the high-order spatial organization of genetic elements. We review progress in unraveling one of the outstanding mysteries of modern biology: the dynamic communication of remote enhancers with target promoters in the specification of cellular identity.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalCell
Volume157
Issue number1
DOIs
StatePublished - Mar 27 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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