Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study

Qianli Wang, Wei Wang, Amy K. Winter, Zhifei Zhan, Marco Ajelli, Filippo Trentini, Lili Wang, Fangcai Li, Juan Yang, Xingyu Xiang, Qiaohong Liao, Jiaxin Zhou, Jinxin Guo, Xuemei Yan, Nuolan Liu, C. Jessica E. Metcalf, Bryan T. Grenfell, Hongjie Yu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for 2.4 months. Following two-dose series of measles-containing vaccine (MCV) at 8 and 18 months of age, the immune protection against measles is not lifelong, and antibody concentrations are extrapolated to fall below the protective threshold of 200 mIU/ml at 14.3 years. A catch-up MCV dose in addition to the routine doses between 8 months and 5 years reduce the cumulative incidence of seroreversion by 79.3–88.7% by the age of 6 years. Our findings also support a good immune response after the first MCV vaccination at 8 months. These findings, coupled with the effectiveness of a catch-up dose in addition to the routine doses, could be instrumental to relevant stakeholders when planning routine immunization schedules and supplemental immunization activities.

Original languageEnglish (US)
Article number1746
JournalNature communications
Volume14
Issue number1
DOIs
StatePublished - Dec 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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