Long-range repression in the Drosophila embryo

Haini N. Cai; David N. Arnosti; Michael Levine

doi:10.1073/pnas.93.18.9309

Long-range repression in the Drosophila embryo

Haini N. Cai, David N. Arnosti, Michael Levine

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74 Scopus citations

Abstract

Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.

Original language	English (US)
Pages (from-to)	9309-9314
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	93
Issue number	18
DOIs	https://doi.org/10.1073/pnas.93.18.9309
State	Published - Sep 3 1996
Externally published	Yes

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AU - Arnosti, David N.

AU - Levine, Michael

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AB - Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.

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Long-range repression in the Drosophila embryo

Abstract

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