Long-range repression in the Drosophila embryo

Haini N. Cai, David N. Arnosti, Michael Levine

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.

Original languageEnglish (US)
Pages (from-to)9309-9314
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number18
StatePublished - Sep 3 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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