Lnc-ing ROR1-HER3 and Hippo signalling in metastasis

Wei Zhuo; Yibin Kang

doi:10.1038/ncb3467

Lnc-ing ROR1-HER3 and Hippo signalling in metastasis

Wei Zhuo
, Yibin Kang

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Nature cell biology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1038/ncb3467
State	Published - Jan 31 2017

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/ncb3467

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abstract = "Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.",

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AU - Kang, Yibin

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AB - Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

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Lnc-ing ROR1-HER3 and Hippo signalling in metastasis

Abstract

All Science Journal Classification (ASJC) codes

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