Lnc-ing ROR1-HER3 and Hippo signalling in metastasis

Wei Zhuo, Yibin Kang

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalNature Cell Biology
Volume19
Issue number2
DOIs
StatePublished - Jan 31 2017

All Science Journal Classification (ASJC) codes

  • Cell Biology

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