Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature Cell Biology|
|State||Published - Jan 31 2017|
All Science Journal Classification (ASJC) codes
- Cell Biology